March 1, 1991European Heart Journal
Persistent inhibition of platelet function during long-term treatment with 75 mg acetylsalicylic acid daily in men with unstable coronary artery disease
Why the study?
Does acetylsalicylic acid 75 mg daily reduce platelet aggregation in men with unstable coronary artery disease?
Population
193 men with unstable coronary artery disease admitted to the Coronary Care Unit
Comparison
Acetylsalicylic acid 75 mg daily started within… vs Placebo
Design
RCT, randomized, double-blind
Follow-up
24 months
Authors
Discussion
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Implication
Low-dose acetylsalicylic acid inhibits platelet aggregation in unstable CAD; confirms efficacy for secondary prevention.
Structured PICO
Does acetylsalicylic acid 75 mg daily reduce platelet aggregation in men with unstable coronary artery disease?
P
Population
193 men with unstable coronary artery disease (unstable angina or non-Q wave myocardial infarction) admitted to the Coronary Care Unit
I
Intervention
Acetylsalicylic acid 75 mg daily started within 72 h of admission
C
Comparator
Placebo
O
Outcome
Platelet function evaluated as ex vivo aggregation toward collagen and ADP before and after 5 days, 1, 12, 18 and 24 months of treatmentsurrogate
Low-dose acetylsalicylic acid (75 mg daily) provides persistent platelet inhibition over 24 months in men with unstable coronary artery disease, though a loading dose exceeding 300 mg is suggested for initial maximal inhibition.
Cite This Study
Berglund et al. (1991) studied this question.