Key result
Acetylsalicylic acid significantly reduced preoperative (200 vs 860 AU min, P<0.001) and postoperative platelet function compared with placebo in patients undergoing non-cardiac surgery.
Why the study?
Does acetylsalicylic acid reduce platelet function in high-risk patients undergoing major non-cardiac surgery?
Population
36 high-risk patients undergoing major non-cardiac surgery
Comparison
Acetylsalicylic acid 75 mg daily from 7 days… vs Placebo
Design
RCT, randomised, double-blind, placebo-controlled
Follow-up
48 h postoperatively
Authors
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Low-dose ASA inhibits platelet function perioperatively in non-cardiac surgery; confirms mechanism and extends RCT evidence to major procedures.
RCT (n=36)
Double-blind
randomised
Yes
Does acetylsalicylic acid reduce platelet function in high-risk patients undergoing major non-cardiac surgery?
Absolute Event Rate: 200% vs 860%
p-value: p=<0.001
Low-dose acetylsalicylic acid effectively inhibits platelet function throughout the perioperative period in patients undergoing major non-cardiac surgery.
Oscarsson et al. (2011) conducted an RCT in High-risk patients undergoing major non-cardiac surgery (n=36). Acetylsalicylic acid vs. Placebo was evaluated on Platelet function in response to arachidonic acid assessed by whole-blood impedance aggregometry (p=<0.001). Acetylsalicylic acid significantly reduced preoperative (200 vs 860 AU min, P<0.001) and postoperative platelet function compared with placebo in patients undergoing non-cardiac surgery.
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