In a study of 41 individuals, chronic hypertension was associated with both increased and subnormal mass of medial smooth muscle in arterioles, depending on proximity to sclerotic segments.
Case-Control (n=41)
Does chronic systemic hypertension alter arteriolar structure compared to normotensive controls?
Chronic systemic hypertension is associated with heterogeneous structural changes in arteriolar medial smooth muscle mass that relate to sclerotic lesions.
A quantitative study of arteriolar structure has been undertaken in 23 individuals with chronic hypertension and 18 normotensive controls. In the hypertensive individuals, some arterioles were found to have an increased, and others a subnormal, mass of medial smooth muscle. Both abnormalities often bear a definite relation to arteriolar sclerotic lesions, those arterioles proximal to sclerotic segments having an increased medial coat and those distal, an atrophic coat. Mean values for mass of arteriolar muscle were often normal in organs of the hypertensive patients. These anatomic features can be correlated with a variety of physiological and clinical observations in the disorder.
Richard L. Naeye (Sat,) conducted a case-control in Chronic systemic hypertension (n=41). Chronic systemic hypertension vs. Normotensive controls was evaluated on Arteriolar structure (mass of medial smooth muscle). In a study of 41 individuals, chronic hypertension was associated with both increased and subnormal mass of medial smooth muscle in arterioles, depending on proximity to sclerotic segments.
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