Key result
Increased intraluminal pressure accelerated intimal thickening in injured rabbit carotid arteries in a time- and pressure-dependent manner up to 130 cmH2O, while higher pressures caused necrosis.
Why the study?
Does increased intraluminal pressure accelerate intimal thickening in injured rabbit carotid arteries?
Does increased intraluminal pressure accelerate intimal thickening in injured rabbit carotid arteries?
Increased intraluminal pressure accelerates intimal thickening in injured arteries up to a threshold, beyond which medial necrosis occurs.
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Hypothesis-generating for pressure effects on vascular remodeling; should not yet influence clinical device deployment strategies.
We developed an organ culture system in order to examine the effect of intraluminal pressure on intimal thickening in injured arteries. After endothelial denudation, an excised rabbit common carotid artery was incubated at 37 degrees C in a glass bottle perfused with Dulbecco's modified Eagle medium containing 10% fetal calf serum at a constant flow rate of 6 ml/h at various static pressure of 60, 95, 130, 165, or 200 cmH2O. Intimal thickening, which consisted of smooth muscle cells and extracellular matrix, increased in a time- and pressure-dependent manner up to 130 cmH2O. Excessive pressured (165 and 200 cmH2O), however, caused necrosis in the media. These results suggest that a rise in intraluminal pressure accelerates intimal thickening in injured arteries.
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Horiuchi et al. (1997) studied Injured arteries. Intraluminal pressure was evaluated on Intimal thickening. Increased intraluminal pressure accelerated intimal thickening in injured rabbit carotid arteries in a time- and pressure-dependent manner up to 130 cmH2O, while higher pressures caused necrosis.
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