Why the study?
Does augmented medial smooth muscle cell necrosis from balloon angioplasty during vasoconstriction increase intimal hyperplasia in normal rabbit femoral arteries?
Population
63 normal femoral arteries of New Zealand White rabbits
Comparison
Overstretching with an angioplasty balloon… vs Overstretching with an angioplasty balloon…
Design
Preclinical
Follow-up
3 days and 3 weeks
Authors
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Extensive medial necrosis during vasoconstriction does not increase intimal hyperplasia after angioplasty in this model; leaves open mechanisms of restenosis in humans.
Does augmented medial smooth muscle cell necrosis from balloon angioplasty during vasoconstriction increase intimal hyperplasia in normal rabbit femoral arteries?
Extensive medial necrosis produced during balloon dilation in maximally vasoconstricted arteries does not lead to more intimal hyperplasia than when less medial necrosis is induced during vasodilation.
Erven et al. (1994) studied this question.
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