Early Identification of Myocardial Microstructural Alterations in Hypertrophic Cardiomyopathy with in Vivo Cardiac Diffusion-Tensor Imaging

Q: What is the clinical evidence from this study?

Study design: Observational. Population: Hypertrophic cardiomyopathy (n=50). Intervention: Hypertrophic cardiomyopathy vs. Healthy volunteers. Primary outcome: Fractional anisotropy (FA).

Q: What does this research mean for the field?

Patients with hypertrophic cardiomyopathy exhibit significantly reduced myocardial fractional anisotropy on in vivo cardiac diffusion-tensor imaging compared with healthy controls. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

Zhixiang Dong; Yun Tang; Peng Sun; Gang Yin; Kankan Zhao; Xuan Ma; Shujuan Yang; Jiaxin Wang; Xiaorui Xiang; Kai Yang; Minjie Lu; Xiuyu Chen; Yanjie Zhu; Shihua Zhao

doi:10.1148/ryct.240009

January 2, 2025Radiology Cardiothoracic ImagingOpen Access

Early Identification of Myocardial Microstructural Alterations in Hypertrophic Cardiomyopathy with in Vivo Cardiac Diffusion-Tensor Imaging

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Key result

Cardiac diffusion-tensor imaging detects microstructural changes in HCM before standard CMR shows hypertrophy or fibrosis.

n=50

Why the study?

Does in vivo cardiac diffusion-tensor imaging (cDTI) help identify abnormal myocardium in patients with hypertrophic cardiomyopathy?

Study Design

Type

Observational (n=50)

Structured PICO

Does in vivo cardiac diffusion-tensor imaging (cDTI) help identify abnormal myocardium in patients with hypertrophic cardiomyopathy?

P

Population

50 participants, comprising 35 with hypertrophic cardiomyopathy and 15 healthy volunteers, evaluated with cardiac MRI.

E

Exposure

In vivo cardiac diffusion-tensor imaging (cDTI) using a 3.0-T scanner

C

Comparator

Healthy volunteers (for group comparison) and normal segments (for segmental analysis)

O

Outcome

Diffusion characteristics (cDTI parameters) and diagnostic performance in discriminating HCM segments from normal segmentssurrogate

Main Result

Absolute Event Rate: 0.33% vs 0.46%

In vivo cardiac diffusion-tensor imaging (cDTI) can identify microstructural alterations, such as reduced fractional anisotropy, in patients with hypertrophic cardiomyopathy compared to healthy controls.

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Implication

May support earlier microstructural assessment in hypertrophic cardiomyopathy; hypothesis-generating and requires prospective validation before clinical adoption.

Abstract

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Discussion

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Cite This Study

Dong et al. (2025) conducted an observational in Hypertrophic cardiomyopathy (n=50). Hypertrophic cardiomyopathy vs. Healthy volunteers was evaluated on Fractional anisotropy (FA). Patients with hypertrophic cardiomyopathy showed reduced fractional anisotropy on cardiac diffusion-tensor imaging compared with healthy controls.

synapsesocial.com/papers/6a0cfb0eb31ab1d6e01e74b6 https://doi.org/10.1148/ryct.240009

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Early Identification of Myocardial Microstructural Alterations in Hypertrophic Cardiomyopathy with in Vivo Cardiac Diffusion-Tensor Imaging

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Early Identification of Myocardial Microstructural Alterations in Hypertrophic Cardiomyopathy with in Vivo Cardiac Diffusion-Tensor Imaging

Study Design

Structured PICO

Main Result

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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