Key result
Electrocardiographically affected LQTS subjects aged 41 to 60 years had a significantly higher risk of aborted cardiac arrest or death compared to unaffected subjects (HR 2.65, P<0.001).
Why the study?
Does the presence of electrocardiographically affected long-QT syndrome increase the risk of aborted cardiac arrest or death in subjects aged 41 to 75 years compared to unaffected subjects?
Cohort (n=2,759)
Yes
Does the presence of electrocardiographically affected long-QT syndrome increase the risk of aborted cardiac arrest or death in subjects aged 41 to 75 years compared to unaffected subjects?
Effect estimate: HR 2.65
p-value: p=<0.001
Patients with long-QT syndrome maintain a significantly elevated risk for life-threatening cardiac events between ages 41 and 60, particularly among women and those with recent syncope or the LQT3 genotype.
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Supports continued vigilance for events in middle-aged LQTS; leaves open extension beyond age 60 and genotype-specific management.
Goldenberg et al. (2008) conducted a cohort in Congenital long-QT syndrome (LQTS) (n=2,759). Electrocardiographically affected (QTc ≥470 ms) vs. Unaffected (QTc <440 ms) and borderline (QTc 440-469 ms) was evaluated on Aborted cardiac arrest or death (HR 2.65, p=<0.001). Electrocardiographically affected LQTS subjects aged 41 to 60 years had a significantly higher risk of aborted cardiac arrest or death compared to unaffected subjects (HR 2.65, P<0.001).
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