Key result
Combined therapy with beta-blockers and continuous pacing kept 28 of 37 patients symptom-free, but a 24% incidence of sudden death or aborted sudden death suggests the need for a backup ICD.
Why the study?
Does combined therapy with beta-blockers and continuous pacing prevent sudden death and symptoms in patients with idiopathic long-QT syndrome?
Population
37 patients with idiopathic long-QT syndrome, mean age 31.6 years, 32 female and 5 male.
Design
Cohort
Follow-up
6.3+/-4.6 years (mean+/-SD)
Authors
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May warrant ICD backup despite symptom control with beta-blocker pacing in long-QT syndrome; leaves open need for randomized confirmation.
Cohort (n=37)
Does combined therapy with beta-blockers and continuous pacing prevent sudden death and symptoms in patients with idiopathic long-QT syndrome?
Combined beta-blocker and continuous pacing therapy provides reasonable symptom control in long-QT syndrome, but the high rate of sudden death or aborted sudden death suggests a need for back-up ICDs.
Dorostkar et al. (1999) conducted a cohort in Idiopathic long-QT syndrome (n=37). Continuous cardiac pacing and beta-blocker therapy was evaluated on Sudden death and aborted sudden death. Combined therapy with beta-blockers and continuous pacing kept 28 of 37 patients symptom-free, but a 24% incidence of sudden death or aborted sudden death suggests the need for a backup ICD.
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