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May 1, 2021Journal of Innovations in Cardiac Rhythm ManagementOpen Access

Catheter Ablation for Brugada Syndrome

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Why the study?

Does epicardial catheter ablation prevent recurrent ventricular fibrillation in patients with drug-refractory Brugada syndrome?

Population

1 55-year-old woman with Brugada syndrome and a subcutaneous implantable cardioverter-defibrillator…

Design

Case_report

Follow-up

5 months

Key result

Epicardial catheter ablation of the right ventricular outflow tract eliminated abnormal local electrical activity and prevented recurrence of ventricular fibrillation over five months of follow-up.

Authors

DQDingxin QinWBWeeranun D. BodeKHKevin Heist

Discussion

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Overview

May support epicardial RVOT ablation in refractory Brugada VF; hypothesis-generating and requires prospective validation.

Study Design

Type

Case Report (n=1)

Multicenter

No

Structured PICO

Does epicardial catheter ablation prevent recurrent ventricular fibrillation in patients with drug-refractory Brugada syndrome?

P
Population
1 55-year-old woman with Brugada syndrome and a subcutaneous implantable cardioverter-defibrillator (ICD), experiencing recurrent polymorphic ventricular tachycardia and ventricular fibrillation (PMVT/VF) despite quinidine therapy.
I
Intervention
Epicardial substrate mapping and radiofrequency catheter ablation targeting fractionated potentials with delayed activation in the anterior right ventricular outflow tract (RVOT).
O
Outcome
Elimination of local abnormal electrograms, disappearance of coved-type ST elevation in V1-V2, and recurrence of ventricular fibrillation.hard clinical

Epicardial substrate modification by catheter ablation in the RVOT may be an effective treatment for symptomatic, drug-refractory Brugada syndrome.

Limitations

  • Single case report
  • Limited follow-up duration
  • Need for multicenter studies to compare mapping and ablation strategies and confirm effectiveness

Cite This Study

Qin et al. (2021) conducted a case report in Brugada syndrome (n=1). Epicardial catheter ablation was evaluated on Recurrence of ventricular fibrillation. Epicardial catheter ablation of the right ventricular outflow tract eliminated abnormal local electrical activity and prevented recurrence of ventricular fibrillation over five months of follow-up.

synapsesocial.com/papers/6a0cfb7332f3c40b5ccbb03ahttps://doi.org/10.19102/icrm.2021.120502
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