Key result
Permanent atrial fibrillation was associated with higher IL-8 levels in the femoral vein compared to paroxysmal AF and controls (4.66 vs 2.97 vs 2.58 pg/mL, P=0.003).
Why the study?
Are inflammatory markers elevated in specific cardiac or peripheral sites in patients with atrial fibrillation compared to controls?
Population
29 patients referred for radiofrequency catheter ablation with no structural heart diseases or inflammatory…
Comparison
Assessment of high-sensitive C-reactive protein… vs Control patients with Wolf-Parkinson-White…
Design
Cross-sectional
Authors
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IL-8 not ready for clinical use in AF; leaves open inflammation's contribution to arrhythmia persistence.
Observational (n=29)
Are inflammatory markers elevated in specific cardiac or peripheral sites in patients with atrial fibrillation compared to controls?
Absolute Event Rate: 4.66% vs 2.58%
p-value: p=0.003
Elevated IL-8 levels in the systemic circulation, right atrium, and coronary sinus of patients with permanent AF suggest a link between low-grade systemic inflammation and long-lasting AF.
Liuba et al. (2008) conducted an observational in Atrial fibrillation (n=29). Permanent atrial fibrillation vs. Paroxysmal atrial fibrillation and WPW syndrome controls was evaluated on Plasma levels of IL-8 in the femoral vein (p=0.003). Permanent atrial fibrillation was associated with higher IL-8 levels in the femoral vein compared to paroxysmal AF and controls (4.66 vs 2.97 vs 2.58 pg/mL, P=0.003).
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