Key result
Permanent AF is linked to higher inflammatory markers and lower endothelial function versus controls.
Why the study?
Whether atrial fibrillation or underlying structural heart disease causes inflammatory activation remains under debate.
Are inflammatory markers and endothelial dysfunction associated with permanent atrial fibrillation independent of underlying structural heart disease?
Population
100 consecutive permanent AF patients and 121 age- and sex-matched sinus rhythm controls
Comparison
Permanent AF patients (with or without structural heart disease) vs sinus rhythm controls
Design
Cross-sectional study
Authors
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Supports inflammation and endothelial dysfunction linked to permanent AF independent of structural heart disease; hypothesis-generating for causality and therapeutic targets.
Cross-Sectional (n=221)
Are inflammatory markers and endothelial dysfunction associated with permanent atrial fibrillation independent of underlying structural heart disease?
Systemic inflammation and endothelial dysfunction are associated with atrial fibrillation itself rather than underlying structural heart disease.
Maida et al. (2020) conducted a cross-sectional in Permanent atrial fibrillation (n=221). Permanent atrial fibrillation vs. Normal sinus rhythm was evaluated on Plasma levels of sIL-2Rα, TNF-α, IL-18 and reactive hyperemia index (RHI). Permanent atrial fibrillation was significantly associated with higher circulating levels of inflammatory markers and lower endothelial function compared to controls.
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