Key result
Chronic atrial fibrillation was independently associated with elevated levels of the thrombogenesis marker F1+2 (p=0.001), but not with the inflammatory marker IL-6 or endothelial activation.
Why the study?
Does chronic atrial fibrillation associate with elevated markers of inflammation, endothelial activation, and thrombogenesis compared to sinus rhythm?
Population
191 consecutive patients with chronic non-rheumatic atrial fibrillation not on anticoagulant therapy and 74…
Comparison
Oral anticoagulation administered to a subset of… vs 74 age- and sex-matched controls in sinus…
Design
Case-control
Authors
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Elevated IL-6 without F1+2 correlation in AF leaves open inflammation's causal role; prospective trials needed before therapeutic targeting.
Observational (n=265)
Does chronic atrial fibrillation associate with elevated markers of inflammation, endothelial activation, and thrombogenesis compared to sinus rhythm?
p-value: p=0.001
Vanessa Roldán (2003) conducted an observational in Chronic non-rheumatic atrial fibrillation (n=265). Chronic non-rheumatic atrial fibrillation vs. Controls in sinus rhythm was evaluated on Plasma levels of F1+2, IL-6, and sEsel (p=0.001). Chronic atrial fibrillation was independently associated with elevated levels of the thrombogenesis marker F1+2 (p=0.001), but not with the inflammatory marker IL-6 or endothelial activation.
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