The Multilayer Flow Modulator reduced average intra-aneurysmal flow velocity by 74.9-87.0% and enstrophy by 96.3-97.5% in in vitro AAA models while preserving incorporated branch perfusion.
Does the Multilayer Flow Modulator (MFM) device reduce intra-aneurysmal flow velocity and vorticity while preserving incorporated branch flow in an experimental AAA model?
The MFM device effectively reduces intra-aneurysmal flow velocity and vorticity while maintaining incorporated branch perfusion and pressure, providing an experimental basis for its potential to reduce type II endoleaks in AAA treatment.
Purpose: To experimentally evaluate the effect of a Multilayer Flow Modulator (MFM) device deployment in an Abdominal Aortic Aneurysm (AAA) model with and without incorporated branch. Methods: An experimental flow and pressure monitoring system was developed to analyze the MFM deployment procedure performed by a qualified radiologist. The pressure and flow rate evolution during the procedure was recorded. Particle Image Velocimetry (PIV) experiments were conducted on models with and without MFM device to evaluate and compare flow patterns and local flow velocity and vorticity in the aneurysm. Results: The experiments revealed no significant change in pressure and flow rate during and after deployment of the MFM device. The flow rate of the incorporated branch was fully preserved. On all models, the aneurysmal flow velocity was significantly reduced. In addition, the device modified local flow patterns, reducing vorticity and better feeding the incorporated branch. Conclusion: This first experimental study provides the basis for a better understanding of the mechanism of the MFM device, which allows intra-aneurysmal flow decrease while preserving incorporated branch and reducing the risk of endoleak type II. The experimental system developed for this study was effective in simulating an endovascular procedure and studying the safety and effectiveness of endovascular devices.
Tupin et al. (Wed,) conducted a other in Abdominal Aortic Aneurysm (AAA). Multilayer Flow Modulator (MFM) vs. Untreated control model was evaluated on Intra-aneurysmal mean flow velocity and enstrophy. The Multilayer Flow Modulator reduced average intra-aneurysmal flow velocity by 74.9-87.0% and enstrophy by 96.3-97.5% in in vitro AAA models while preserving incorporated branch perfusion.