Key result
Computational modeling shows females with LQTS exhibit greater susceptibility to EADs than males.
Why the study?
To explore sex disparities in long QT syndrome using sex-specific human ventricular cardiomyocyte models.
Does sex affect susceptibility to early afterdepolarizations in computational models of long QT syndrome?
Does sex affect susceptibility to early afterdepolarizations in computational models of long QT syndrome?
Computational modeling reveals that female human ventricular cardiomyocytes have greater susceptibility to early afterdepolarizations in long QT syndrome compared to males, driven by specific ionic current differences.
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May warrant sex-specific LQTS risk modeling; leaves open clinical validation of these computational findings.
Doherty et al. (2025) studied Long QT syndrome (LQTS). Female ventricular cardiomyocyte models vs. Male ventricular cardiomyocyte models was evaluated on Susceptibility to early afterdepolarizations (EADs). Computational modeling of human ventricular cardiomyocytes showed that females exhibit greater susceptibility to early afterdepolarizations than males in long QT syndrome.
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