Key result
GSK3β-dependent modulation of voltage-gated ion channels shapes neuronal plasticity as a potential neurotherapeutic target.
Why the study?
Although the full range of molecular targets of GSK3β is unknown, recent results identify voltage-gated ion channels among its downstream targets.
Design
Review
Authors
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May support neurotherapeutic target exploration; leaves open clinical translation pending prospective trials.
GSK3β modulates voltage-gated ion channels in the central nervous system, presenting a potential pharmacological target for neurotherapeutic development.
Marosi et al. (2022) conducted a review in Neuropsychiatric disorders. GSK3β-dependent modulation of voltage-gated ion channels influences neuronal plasticity and may serve as an important pharmacological target for neurotherapeutic development.
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