Obesity as Compared With Physical Activity in Predicting Risk of Coronary Heart Disease in Women
Key result
Obesity and physical inactivity were associated with a significantly higher risk of incident major CHD events compared to being healthy weight and active (RR 3.44; 95% CI 2.81-4.21).
Why the study?
Do obesity and physical inactivity independently increase the risk of incident major CHD events in women without baseline cardiovascular disease?
Population
88,393 women, 34 to 59 years of age, in the Nurses' Health Study without cardiovascular disease and cancer…
Comparison
Obesity and physical inactivity vs Healthy weight and physically active
Design
Cohort
Follow-up
20 years
Authors
Discussion
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Implication
Supports counseling on weight and activity for women without CVD; leaves open causal effects and intervention benefits.
Study Design
Type
Cohort (n=88,393)
Structured PICO
Do obesity and physical inactivity independently increase the risk of incident major CHD events in women without baseline cardiovascular disease?
P
Population
88,393 women, 34 to 59 years of age, in the Nurses' Health Study without cardiovascular disease and cancer at baseline.
I
Intervention
Obesity (BMI ≥30 kg/m2) and physical inactivity (exercise <1 h/wk)
C
Comparator
Healthy weight (BMI 18.5 to 24.9 kg/m2) and physically active (exercise ≥3.5 h/wk)
O
Outcome
Incident major CHD events (including nonfatal myocardial infarction and fatal CHD)hard clinical
Main Result
Effect estimate: RR 3.44 (95% CI 2.81 to 4.21)
Obesity and physical inactivity independently contribute to the development of CHD in women, underscoring the importance of both maintaining a healthy weight and regular physical activity.
Cite This Study
Li et al. (2006) conducted a cohort in Coronary heart disease (n=88,393). Obesity and physical inactivity vs. Healthy weight and physically active was evaluated on Incident major CHD events (including nonfatal myocardial infarction and fatal CHD) (RR 3.44, 95% CI 2.81 to 4.21). Obesity and physical inactivity were associated with a significantly higher risk of incident major CHD events compared to being healthy weight and active (RR 3.44; 95% CI 2.81-4.21).