Key result
Exosomes mediate vascular remodeling via intercellular communication to drive hypertension and atherosclerosis.
Why the study?
Exosomes are emerging as vital mediators of vascular remodeling in diseases like essential hypertension, atherosclerosis, and pulmonary arterial hypertension, warranting a review of their role in intercellular communication.
This review highlights the emerging role of exosomes as mediators of vascular remodeling and potential biomarkers or therapeutics in vascular diseases such as hypertension, atherosclerosis, and pulmonary arterial hypertension.
Exosomes offer no immediate clinical applications in vascular disease; leaves open their validation as biomarkers or targets.
Exosomes are biological small spherical lipid bilayer vesicles secreted by most cells in the body. Their contents include nucleic acids, proteins, and lipids. Exosomes can transfer material molecules between cells and consequently have a variety of biological functions, participating in disease development while exhibiting potential value as biomarkers and therapeutics. Growing evidence suggests that exosomes are vital mediators of vascular remodeling. Endothelial cells (ECs), vascular smooth muscle cells (VSMCs), inflammatory cells, and adventitial fibroblasts (AFs) can communicate through exosomes; such communication is associated with inflammatory responses, cell migration and proliferation, and cell metabolism, leading to changes in vascular function and structure. Essential hypertension (EH), atherosclerosis (AS), and pulmonary arterial hypertension (PAH) are the most common vascular diseases and are associated with significant vascular remodeling. This paper reviews the latest research progress on the involvement of exosomes in vascular remodeling through intercellular information exchange and provides new ideas for understanding related diseases.
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Ren et al. (2023) conducted a review in Vascular diseases (Essential hypertension, atherosclerosis, pulmonary arterial hypertension). Exosomes was evaluated. Exosomes act as vital mediators of vascular remodeling through intercellular communication, playing a key role in the development of vascular diseases such as hypertension and atherosclerosis.
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