Key result
GDF11 activates smad signaling in HUVECs but fails to affect endothelial proliferation and migration.
Why the study?
Does GDF11 improve proliferation and migration in human umbilical vein endothelial cells and primary rat aortic endothelial cells?
Population
Human umbilical vein endothelial cells (HUVECs) and primary rat aortic endothelial cells (RAECs)
Comparison
GDF11/BMP11 vs Untreated control
Design
Preclinical
Authors
Loading...
GDF11 activates Smad signaling without affecting endothelial proliferation or migration; leaves open its vascular rejuvenation role pending higher-level evidence.
Does GDF11 improve proliferation and migration in human umbilical vein endothelial cells and primary rat aortic endothelial cells?
GDF11 activates smad signaling but does not significantly affect endothelial cell proliferation or migration, challenging its proposed role as a vascular rejuvenation factor.
Zhang et al. (2016) studied Endothelial cell function. GDF11/BMP11 was evaluated on Proliferation and migration of HUVECs and RAECs, and smad signaling activation. GDF11 activated both smad1/5/8 and smad2/3 signals in HUVECs but showed no significant effect on endothelial cell proliferation and migration.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: