Key result
TGF-beta1 regulates the autocrine induction of bFGF in primary human lung fibroblasts, resulting in delayed activation of the ERK pathway and induction of AP-1 binding.
Population
Primary human lung fibroblasts
Design
Preclinical
Authors
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Hypothesis-generating for fibrotic mechanisms; leaves open therapeutic relevance without in vivo validation.
TGF-beta1 induces ERK pathway activation and AP-1 binding in human lung fibroblasts via autocrine induction of bFGF, elucidating a molecular mechanism relevant to fibrotic lung diseases.
Finlay et al. (2000) studied Fibrotic lung diseases. TGF-beta1 was evaluated on ERK pathway activation and AP-1 binding. TGF-beta1 regulates the autocrine induction of bFGF in primary human lung fibroblasts, resulting in delayed activation of the ERK pathway and induction of AP-1 binding.
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