Key result
Experimental pericardial tamponade induced negative transmural atrial pressures when pericardial pressure reached 130 mm H2O, whereas pneumothorax producing similar pressures did not.
Population
14 anesthetized, open-chest dogs (and an unspecified number of closed-chest dogs)
Comparison
Progressive injection of saline or air into the… vs Air inflation of pleural space in closed-chest…
Design
Preclinical
Authors
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Distinguishes pericardial from pleural pressure effects on atrial transmural pressures in animal models; leaves open translation to human tamponade.
Pericardial filling stiffens surrounding structures, diminishing atrial wall collapsibility and allowing some cardiac filling even during marked tamponade.
Brecher et al. (1971) studied Pericardial tamponade (n=14). Pericardial tamponade (saline or air injection into pericardial sac) vs. Pneumothorax (air inflation of pleural space) was evaluated on Transmural atrial pressure (TAP). Experimental pericardial tamponade induced negative transmural atrial pressures when pericardial pressure reached 130 mm H2O, whereas pneumothorax producing similar pressures did not.
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