Key result
Left ventricular diastolic pressure-volume relations in conscious dogs were approximately exponential, and end-diastolic pressure was not a reliable index of end-diastolic volume or compliance.
Population
7 conscious dogs with left ventricular cavity outlined by permanent radiopaque markers and implanted…
Design
Preclinical
Authors
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Challenges reliance on end-diastolic pressure for LV assessment; leaves open validation of exponential relations in humans.
In conscious dogs, the left ventricular diastolic pressure-volume relationship is approximately exponential and primarily determined by elastic properties, suggesting end-diastolic pressure is not a reliable index of end-diastolic volume or compliance.
Noble et al. (1969) studied Left ventricular mechanics (n=7). Infusions of saline, isoproterenol, calcium gluconate, and methoxamine was evaluated on Left ventricular diastolic pressure-volume relationship. Left ventricular diastolic pressure-volume relations in conscious dogs were approximately exponential, and end-diastolic pressure was not a reliable index of end-diastolic volume or compliance.