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March 1, 1972Cardiovascular Research

Left ventricular pressure-dimension relationships in the conscious dog

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Population

conscious sedated dogs

Comparison

isoproterenol and metaraminol infusions vs at rest

Design

Preclinical

Authors

LHLawrence D. HorwitzUniversity of Colorado Anschutz Medical CampusVBV. S. BishopBishop's University

Discussion

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Implication

Challenges linear LV diastolic models in research; leaves open translation to human disease states.

Key Points

  • This research aims to explore the relationships between internal diameter, pressure, and flow in the left ventricle of conscious sedated dogs.
  • Conducted on conscious sedated dogs at rest and during drug infusions.
  • Assessed left ventricular function using internal diameter and pressure measurements.
  • Analyzed the diastolic pressure-diameter curve for dynamic function.
  • The diastolic pressure-diameter curve was sigmoidal in shape.
  • Early diastolic pressure was negative and influenced by viscous forces.
  • Inertial forces also likely affected the pressure-dimension relationships observed.

Structured PICO

P
Population
conscious sedated dogs
I
Intervention
isoproterenol and metaraminol infusions
C
Comparator
at rest
O
Outcome
left ventricular internal diameter, pressure, and flowsurrogate

In conscious sedated dogs, the left ventricular diastolic pressure-diameter curve is sigmoidal and influenced by viscous and inertial forces.

Cite This Study

Horwitz et al. (1972) studied this question.

synapsesocial.com/papers/6a1bf4856f692abb725efda5https://doi.org/10.1093/cvr/6.2.163
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Left Ventricular Filling and Diastolic Pressure-Volume Relations in the Conscious Dog1969 · 120 citations
  2. 2Systolic pressure--diameter relations in the normal conscious dog1975 · 147 citations
  3. 3The three-dimensional dynamic geometry of the left ventricle in the conscious dog.1976 · 343 citations
  4. 4Simultaneous determination of left ventricular end-systolic pressure-volume and pressure-dimension relationships in closed-chest dogs.1985 · 71 citations
  5. 5Dlastolic Pressure-Volume Relationship in the Canine Left Ventricle1971 · 151 citations