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Fractional CO2 laser provides significantly greater improvements in postcesarean scar quality and related symptoms at 6 months compared to topical silicone gel, with a comparable safety profile. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

May 20, 2026Clinical Cosmetic and Investigational DermatologyOpen Access

Comparative Effectiveness of Fractional CO2 Laser and Topical Silicone Gel for Postcesarean Scars

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Authors

YWYi WangFujian Medical University MCMinjian ChenFujian Medical University ZWZhenni WeiFujian Medical University

Discussion

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Implication

Retrospective cohort study compares fractional CO2 laser and silicone gel for scar improvement, suggesting laser is more effective.

Key Points

This study aims to compare the effectiveness of fractional CO2 laser and topical silicone gel for improving postcesarean scars.
Retrospective cohort study including 220 women with postcesarean scars, treated with either fractional CO2 laser or silicone gel.
Both groups received standard postoperative scar care; primary outcome assessed using the Vancouver Scar Scale at 6 months.
Data analyzed using unadjusted comparisons and analysis of covariance for baseline adjustments.
Laser group demonstrated better scar quality at 6 months (VSS total: 4.185 vs 4.619, P=0.003).
Adjusted mean difference in VSS score favored the laser group (−0.643; 95% CI −0.891 to −0.395; P<0.001).
Significant improvements in vascularity, pigmentation, and patient satisfaction were observed with laser treatment (all P<0.001).

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4e9df03e14405aa99d25 https://doi.org/10.2147/ccid.s596343

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May 20, 2026Clinical Cosmetic and Investigational DermatologyOpen Access

Comparative Effectiveness of Fractional CO2 Laser and Topical Silicone Gel for Postcesarean Scars

View Full Paper

Ask AI

Bookmark

Authors

YWYi WangFujian Medical University MCMinjian ChenFujian Medical University ZWZhenni WeiFujian Medical University

Discussion

Member takes

Implication

Retrospective cohort study compares fractional CO2 laser and silicone gel for scar improvement, suggesting laser is more effective.

Key Points

This study aims to compare the effectiveness of fractional CO2 laser and topical silicone gel for improving postcesarean scars.
Retrospective cohort study including 220 women with postcesarean scars, treated with either fractional CO2 laser or silicone gel.
Both groups received standard postoperative scar care; primary outcome assessed using the Vancouver Scar Scale at 6 months.
Data analyzed using unadjusted comparisons and analysis of covariance for baseline adjustments.
Laser group demonstrated better scar quality at 6 months (VSS total: 4.185 vs 4.619, P=0.003).
Adjusted mean difference in VSS score favored the laser group (−0.643; 95% CI −0.891 to −0.395; P<0.001).
Significant improvements in vascularity, pigmentation, and patient satisfaction were observed with laser treatment (all P<0.001).

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4e9df03e14405aa99d25 https://doi.org/10.2147/ccid.s596343

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