This randomized trial demonstrates improved osteoinductivity in titanium alloys with a composite chitosan coating, indicating enhanced bonding with bone.
The objective of this study is to develop a composite coating using chitosan (Chit), hydroxyapatite (HAp), and vascular endothelial growth factor-A (VEGF). The bioactive coating was created through the electrochemical deposition of chitosan onto a laser-treated titanium alloy surface, followed by the adsorption of VEGF. Our in vitro experiments have shown that this discs with laser-engraved parallel linear grooves and bioactive coating enhances the adhesion of human mesenchymal stromal cells and exhibits osteoinductive and proangiogenic properties in vitro. This combination of the VEGF-loaded composite coating and substrate microrelief will enhance osteointegration and osteosynthesis at the bone interface.
No takes yet. Share an insight, caveat, or question.
Makrinskiy et al. (2025) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: