What question did this study set out to answer?

To evaluate constitutive modelling as a mechanistic framework bridging arterial wall microstructure—composed of elastin, collagen, and vascular smooth muscle cells—with clinical indices of arterial function.

May 20, 2026Artery ResearchOpen Access

A Constitutive Modelling Outlook on Arterial (dys)function: Bridging the Gap with the Clinic

Q: What is the clinical evidence from this study?

Study design: Review. Population: Arterial dysfunction. Intervention: Constitutive modelling.

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Key result

Constitutive modelling of microstructural constituents clarifies whole-artery mechanics to provide insights into aging and disease.

Why the study?

Conventional clinical vascular indices characterise functional consequences of vascular ageing but provide limited mechanistic insight into underlying microstructural remodelling processes.

Key Points

To evaluate constitutive modelling as a mechanistic framework bridging arterial wall microstructure—composed of elastin, collagen, and vascular smooth muscle cells—with clinical indices of arterial function.
Synthesized constitutive modelling applications from prior experimental and numerical studies, covering passive and active whole-artery biomechanics in murine thoracic aortas.
Formulated multi-scale models of the tri-layered arterial wall to evaluate mechanical constituent contributions across physiological pressure ranges.
Simulations demonstrated that elastin bears the primary mechanical load at passive pressures below ~150 mmHg, while collagen fibers recruit at pressures above 60 mmHg to provide structural protection.
Constitutive formulations disentangled microstructural determinants of viscoelasticity and identified the ascending aorta as the principal anatomical determinant of windkessel function.
Extensive biomechanical data requirements were highlighted as the key barrier to clinical translation, with mechanobiological constraints and multi-bed waveform acquisitions proposed as parameterization solutions.

PICO

Population

Arterial dysfunction

Intervention / Comparator

Constitutive modelling

Constitutive modelling offers a promising framework to understand the microstructural determinants of arterial aging and disease, though clinical translation requires strategies to overcome data limitations for model parameterization.

Limitations

Scarcity of human tissue for ex vivo testing
Sparsity of arterial biomechanical data that can be acquired clinically in vivo
Risk of overfitting when parametrising complex models on sparse in vivo data
Extensive biomechanical data for model parametrisation is the main limiting factor to widespread adoption in clinical settings.

Discussion

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Implication

May advance microstructural insights into arterial aging and disease; leaves open clinical translation until parameterization data limitations are overcome.

Cite This Study

A. Giudici (2026) conducted a review in Arterial dysfunction. Constitutive modelling was evaluated. Constitutive modelling provides a useful framework to represent whole-artery mechanics as superimposed contributions of microstructural constituents, offering insights into arterial ageing and disease.

synapsesocial.com/papers/6a0d4efcf03e14405aa9a365 https://doi.org/10.1007/s44200-026-00116-z

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Implication

May advance microstructural insights into arterial aging and disease; leaves open clinical translation until parameterization data limitations are overcome.

A Constitutive Modelling Outlook on Arterial (dys)function: Bridging the Gap with the Clinic

Key Points

PICO

Limitations

Discussion

Implication

Cite This Study

A Constitutive Modelling Outlook on Arterial (dys)function: Bridging the Gap with the Clinic

Key Points

PICO

Limitations

Discussion

Implication

Cite This Study

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