Randomized trial evaluates hepatoprotective effects of Centaurea pungens extract in rats, suggesting potential liver disorder treatment.
The study evaluated the antioxidant and hepatoprotective potential of the n-butanol extract of Centaurea pungens (BECP) against carbon tetrachloride (CCl4)-induced hepatotoxicity in Wistar rats. The safety of BECP was demonstrated through acute cytotoxicity tests and MTT assays. BECP showed in vitro radical scavenging activity. Pretreatment with BECP (100, 200, and 400 mg/kg) significantly alleviated liver markers in a dose-dependent manner, restoring antioxidant status. The results suggested that Centaurea pungens exerts strong hepatoprotective effects mediated by bioactive compounds identified by total phenolic content and LC-MS analysis, supporting its potential in liver disorder treatment.
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Mezdour et al. (2026) studied this question.
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