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This study aims to evaluate antimicrobial resistance patterns and clinical predictors of resistance in Helicobacter pylori infections.

May 20, 2026MicroorganismsOpen Access

Antimicrobial Resistance Patterns and Predictors in Helicobacter pylori Infection: A Real-World Cohort Study

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Cohort study finds high antimicrobial resistance rates in Helicobacter pylori infections, suggesting tailored treatment strategies are needed.

This study aims to evaluate antimicrobial resistance patterns and clinical predictors of resistance in Helicobacter pylori infections.
Retrospective observational cohort study including 352 adult patients with confirmed Helicobacter pylori infection.
Antimicrobial susceptibility testing performed on cultures from 168 patients; 184 patients received empirical therapy.
Multivariable logistic regression analysis used to identify independent predictors of resistance.
Resistance to at least one antimicrobial agent was detected in 44.6% of susceptibility-tested patients.
Clarithromycin resistance was 42.5%, metronidazole 36.4%, and levofloxacin 14.0%; amoxicillin resistance was low at 2.4%.
Prior eradication therapy was an independent predictor of resistance (aOR 2.41; 95% CI 1.29–4.51; p=0.006).

Matei et al. (2026) studied this question.

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Cohort study finds high antimicrobial resistance rates in Helicobacter pylori infections, suggesting tailored treatment strategies are needed.