What does this research mean for the field?

Prior H. pylori treatment, Black race, and Hispanic ethnicity are independent predictors of antimicrobial resistance in pediatric H. pylori infections. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to identify predictors of antimicrobial resistance in pediatric Helicobacter pylori infections.

June 10, 2026PathogensOpen Access

Predictors of Resistance in Pediatric Helicobacter pylori Infection

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Authors

KRKim Ruiz-ArellanosBoston Children's Hospital MCMaria Camila Cardenas-FernándezBoston Children's Hospital SBSilvana BonillaBoston Children's Hospital

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Implication

Retrospective cohort study identifies factors associated with antimicrobial resistance in children, influencing treatment strategies.

Key Points

The aim is to identify predictors of antimicrobial resistance in pediatric Helicobacter pylori infections.
Conducted a retrospective cohort study of 174 patients with H. pylori-positive gastric biopsy cultures from 2020 to 2025 at a pediatric tertiary care center.
Used descriptive statistics and logistic regression models to analyze demographic factors, prior treatment history, and antimicrobial resistance.
Evaluated resistance rates against multiple antibiotics including metronidazole and clarithromycin.
50.3% of patients exhibited resistance to at least one antimicrobial with specific rates of 28.3% for metronidazole and 18.5% for clarithromycin.
Prior treatment history was the most consistent predictor of antimicrobial resistance.
Black and Hispanic patients showed significantly higher odds of metronidazole resistance compared to their White counterparts.

Cite This Study

Ruiz-Arellanos et al. (2026) studied this question.

synapsesocial.com/papers/6a28fff36f82f25be989ca89 https://doi.org/10.3390/pathogens15060608

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Predictors of Resistance in Pediatric Helicobacter pylori Infection

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Implication

Key Points

Cite This Study

Predictors of Resistance in Pediatric Helicobacter pylori Infection

Discussion

Member takes

Implication

Key Points

Cite This Study

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