What question did this study set out to answer?

This research aims to assess the effects of buffered permissive hypercapnia on right ventricular function in acute RV failure.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

A56-09 Preliminary Findings on Buffered Permissive Hypercapnia in Acute Right Ventricular Failure: Pathophysiological Insights From Preclinical Models of Right Heart Failure - The Pharaoh Right Ventricle Study

View Full Paper

Ask AI

Bookmark

Authors

FBF BaccoliSociety of Critical Care Medicine HNH NonakaSociety of Critical Care Medicine JBJ BoeschSociety of Critical Care Medicine

Discussion

Member takes

Implication

Randomized crossover preclinical trial investigates buffered permissive hypercapnia's impact on RV function in ovine models, suggesting physiological benefits.

Key Points

This research aims to assess the effects of buffered permissive hypercapnia on right ventricular function in acute RV failure.
Prospective, randomized crossover preclinical study in ovine models of acute RV failure.
Induced RV failure through pulmonary artery banding or myocardial injury with ethanol injections.
Sequential application of permissive and buffered permissive hypercapnia with monitoring via Swan-Ganz catheter.
RV ejection fraction increased from 35% (permissive hypercapnia) to 42% (buffered permissive hypercapnia).
Mechanical power decreased from 11 J/min during permissive hypercapnia to 14 J/min with buffering.
Pulmonary vascular resistance improved from 8.2 to 6.3 Wood units with buffered permissive hypercapnia.

Cite This Study

Baccoli et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fbff03e14405aa9b243 https://doi.org/10.1093/ajrccm/aamag162.4639

View Full Paper

Ask AI

Bookmark

Implication

Randomized crossover preclinical trial investigates buffered permissive hypercapnia's impact on RV function in ovine models, suggesting physiological benefits.

A56-09 Preliminary Findings on Buffered Permissive Hypercapnia in Acute Right Ventricular Failure: Pathophysiological Insights From Preclinical Models of Right Heart Failure - The Pharaoh Right Ventricle Study

Discussion

Member takes

Implication

Key Points

Cite This Study

A56-09 Preliminary Findings on Buffered Permissive Hypercapnia in Acute Right Ventricular Failure: Pathophysiological Insights From Preclinical Models of Right Heart Failure - The Pharaoh Right Ventricle Study

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider