What question did this study set out to answer?

To determine whether acute and chronic hypercapnic acidosis impairs right ventricular myocardial function during normal and increased afterload conditions.

January 1, 1983Circulation Research

Right ventricular performance during increased afterload impaired by hypercapnic acidosis in conscious dogs.

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Why the study?

Does hypercapnic acidosis impair right ventricular performance during increased afterload in conscious dogs?

Population

5 conscious dogs

Comparison

Acute and chronic hypercapnic acidosis during… vs Normocapnic control

Design

Preclinical

Follow-up

2 weeks

Authors

CRCharles E. RoseCenters for Disease Control and Prevention KBK Van Benthuysen JJJesse JacksonJackson College

Discussion

Member takes

Implication

Hypercapnic acidosis may worsen right ventricular compliance during afterload stress in dogs; leaves open relevance to heart failure in pulmonary hypertension with CO2 retention.

Key Points

To determine whether acute and chronic hypercapnic acidosis impairs right ventricular myocardial function during normal and increased afterload conditions.
Evaluated 5 conscious dogs exposed to acute (2 hours; PaCO2 = 49 ± 3 mm Hg, pH = 7.27 ± 0.003) and chronic (2 weeks; PaCO2 = 55 ± 2 mm Hg, pH = 7.28 ± 0.01) hypercapnic acidosis.
Increased right ventricular afterload using progressive balloon occlusion of the right ventricular outflow tract with and without beta-adrenergic blockade.
Acute hypercapnic acidosis during elevated afterload increased the slope of right ventricular end-diastolic pressure 4-fold (P < 0.01) compared to normocapnic control, while maximum isovolumic dP/dt rose similarly (P < 0.05).
Chronic hypercapnic acidosis during elevated afterload doubled the rate of rise in right ventricular end-diastolic pressure (P < 0.01) over control, while maximum dP/dt remained unchanged and cardiac output fell.
Beta-adrenergic blockade increased (P < 0.01) the rate of rise in right ventricular end-diastolic pressure during increased afterload in both normocapnic control and chronic hypercapnic acidosis.

Structured PICO

Does hypercapnic acidosis impair right ventricular performance during increased afterload in conscious dogs?

Population

5 conscious dogs

Intervention

Acute (2 hours) and chronic (2 weeks) hypercapnic acidosis during normal and increased right ventricular afterload (via progressive balloon occlusion of the right ventricular outflow tract)

Comparator

Normocapnic control

Outcome

Right ventricular performance (including right ventricular end-diastolic pressure, maximum isovolumic right ventricular dP/dt, cardiac output, and stroke work)surrogate

Hypercapnic acidosis impairs right ventricular performance during increased afterload, suggesting a mechanism for congestive heart failure in patients with pulmonary hypertension and CO2 retention.

Cite This Study

Rose et al. (1983) studied this question.

synapsesocial.com/papers/6a725f4c2163a0a01bc61575 https://doi.org/10.1161/01.res.52.1.76

Topics

Heart failure HFrEF treatment

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Implication

Hypercapnic acidosis may worsen right ventricular compliance during afterload stress in dogs; leaves open relevance to heart failure in pulmonary hypertension with CO2 retention.

Right ventricular performance during increased afterload impaired by hypercapnic acidosis in conscious dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Right ventricular performance during increased afterload impaired by hypercapnic acidosis in conscious dogs.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider