Key result
In dogs, hypoxia decreased left ventricular diastolic dimensional distensibility, an effect that was completely abolished by the addition of hypercapnia.
Why the study?
Do hypoxia and hypercapnia alter left ventricular relaxation and chamber stiffness in dogs?
Population
Dogs in an open-chest, open-pericardium preparation
Comparison
Hypoxia and hypoxia-hypercapnia vs Baseline and pulmonary artery occlusion
Design
Preclinical
Authors
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Hypercapnia may offset hypoxia effects on LV distensibility; hypothesis-generating for human diastolic function and should not change practice.
Do hypoxia and hypercapnia alter left ventricular relaxation and chamber stiffness in dogs?
In a canine model, hypoxia decreases left ventricular diastolic distensibility, but this effect is completely abolished by concurrent hypercapnia.
Gómez et al. (1992) studied Hypoxemia and hypercapnia. Hypoxia and hypoxia-hypercapnia vs. Baseline and pulmonary artery occlusion was evaluated on Left ventricular diastolic dimensional distensibility (DD). In dogs, hypoxia decreased left ventricular diastolic dimensional distensibility, an effect that was completely abolished by the addition of hypercapnia.
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