Why the study?
Does acute hypoxia alter left ventricular contractility and diastolic function in an open-chest dog model?
Does acute hypoxia alter left ventricular contractility and diastolic function in an open-chest dog model?
Acute hypoxia initially enhances LV contractility and diastolic function, but subsequent hypercapnic acidosis depresses both systolic and diastolic functions.
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Animal data show acidosis reverses early hypoxic LV gains; hypothesis-generating, leaves open human relevance.
Maruyama et al. (1992) studied this question.
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