What question did this study set out to answer?

This case report aims to clarify the diagnostic challenges faced in distinguishing between methotrexate-induced lung injury and psoriasis-associated interstitial lung disease (ILD).

May 20, 2026American Journal of Respiratory and Critical Care Medicine

C42-50 Chronic Interstitial Lung Disease in a Patient With Long-Term Methotrexate Therapy for Psoriasis: A Diagnostic Challenge Between Methotrexate-Induced Lung Injury and Psoriasis-Associated ILD

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Authors

JFJ B FoscabloPhilippine General Hospital KMK E MurilloPhilippine General Hospital DCD E ClederaPhilippine General Hospital

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Implication

Case presentation highlights diagnostic challenges between methotrexate-induced lung injury and psoriasis-associated ILD.

Key Points

This case report aims to clarify the diagnostic challenges faced in distinguishing between methotrexate-induced lung injury and psoriasis-associated interstitial lung disease (ILD).
Case presentation of a 61-year-old man with a long history of psoriasis on methotrexate treatment.
Evaluation based on chest CT scans, pulmonary function tests, and patient medical history.
Assessment of clinical symptoms including cough, neck pain, and chest pain.
CT imaging revealed subpleural blebs and bilateral lower-lobe interstitial alterations.
Pulmonary function tests indicated a restrictive pattern with reduced DLCO.
The findings suggest a diagnosis more in line with psoriasis-associated ILD rather than classic methotrexate-induced pneumonitis.

Cite This Study

Foscablo et al. (2026) studied this question.

synapsesocial.com/papers/6a0d4fbff03e14405aa9b260 https://doi.org/10.1093/ajrccm/aamag162.2734

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C42-50 Chronic Interstitial Lung Disease in a Patient With Long-Term Methotrexate Therapy for Psoriasis: A Diagnostic Challenge Between Methotrexate-Induced Lung Injury and Psoriasis-Associated ILD

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Cite This Study

C42-50 Chronic Interstitial Lung Disease in a Patient With Long-Term Methotrexate Therapy for Psoriasis: A Diagnostic Challenge Between Methotrexate-Induced Lung Injury and Psoriasis-Associated ILD

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