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This review aims to assess the current state of sonodynamic therapy in glioblastoma and its challenges for clinical application.

May 20, 2026npj AcousticsOpen Access

Preclinical evidence of sonodynamic therapy in glioblastoma and challenges towards clinical translation: a review of the literature

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Review highlights challenges in translating sonodynamic therapy findings from preclinical to clinical settings in glioblastoma.

This review aims to assess the current state of sonodynamic therapy in glioblastoma and its challenges for clinical application.
Conducted a systematic literature search to identify preclinical studies on sonodynamic therapy in glioblastoma.
Focused on analyzing thirteen preclinical studies and six clinical trials regarding SDT's effectiveness and protocols.
Confirmed the tumoricidal effects of sonodynamic therapy in preclinical studies with variable ultrasound parameters.
Identified six clinical trials with heterogeneous protocols indicating challenges in standardization and translation of findings to clinical use.

Özdemir et al. (2026) studied this question.

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