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May 20, 2026American Journal of Respiratory and Critical Care Medicine

A102-02 Podocyte Under Pressure: Collapsing Lupus Podocytopathy Diagnosed When Kidney Biopsy Beat the Marrow Call

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Authors

YLY LiuAGA GaniRAR S Ahmad

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Overview

Randomized trial shows the importance of early kidney biopsy in severe nephrotic-range proteinuria cases, indicating autoimmunity-related injuries.

Key Points

  • This case examines the severe manifestation of collapsing lupus podocytopathy and highlights the critical role of timely kidney biopsy and treatment.
  • 60-year-old male with acute kidney injury, nephrotic-range proteinuria, and elevated autoimmune markers was biopsied.
  • Immunosuppressive therapy was initiated with IV methylprednisolone after diagnosis.
  • The findings from kidney biopsy were analyzed for histologic damage and immune complex deposits.
  • The kidney biopsy confirmed collapsing FSGS with significant tubule damage (∼80% atrophy/interstitial fibrosis).
  • Elevated autoimmune markers indicated a probable diagnosis of lupus podocytopathy rather than paraprotein-related damage.
  • Patient was discharged on prednisone taper with a poor prognosis for renal recovery.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5013f03e14405aa9ba10https://doi.org/10.1093/ajrccm/aamag162.3202
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Lupus podocytopathy with focal segmental glomerulosclerosis pattern and anti-neutrophil cytoplasmic antibody positivity: a case report2026
  2. 2Risk factors for acute kidney injury and kidney relapse in patients with lupus podocytopathy2024 · 10 citations
  3. 3Unmasking Focal Segmental Glomerulosclerosis in a Patient With Lupus Nephritis2024
  4. 4Lupus Podocytopathy as a First Renal Manifestation in Long-standing Systemic Lupus Erythematosus: A case report2025
  5. 5Lupus-associated collapsing glomerulopathy; a current data2024