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May 20, 2026Current Opinion in Pulmonary Medicine

Precision immunosuppression in adult lung transplantation: are we there yet?

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Authors

PJPéter JakschBarmherzige Schwestern Krankenhaus WienABAlberto BenazzoVienna General HospitalGMGabriella MurakoezyMedical University of Vienna

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Implication

Review highlights the promise of individualized immune management to enhance outcomes in lung transplantation, suggesting new strategies and biomarkers for better patient care.

Key Points

  • This review examines the limitations of traditional immunosuppression in lung transplantation and explores emerging personalized strategies.
  • Discussed recent findings on biomarkers like Torque Teno virus load and donor-derived cell-free DNA for immune monitoring.
  • Evaluated pharmacogenomic profiling and immunomodulatory techniques, including extracorporeal photopheresis, for tailored therapies.
  • Highlighted the integration of blood and bronchoalveolar lavage-based biomarkers for early detection of complications.
  • Identified Torque Teno virus load as a marker for net immunosuppression.
  • Showcased donor-derived cell-free DNA as an effective indicator of graft injury.
  • Demonstrated that combining risk stratification and biomarkers can lead to safer immunosuppression approaches.

Cite This Study

Jaksch et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5098f03e14405aa9c774https://doi.org/10.1097/mcp.0000000000001281
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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