What does this research mean for the field?

The Duke Activity Status Index (DASI) is a valid tool for estimating functional capacity in patients with COPD, demonstrating moderate positive correlations with absolute and relative VO2 during cardiopulmonary exercise testing. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The aim is to create a model using the DASI for estimating functional capacity and its role as a prognostic marker in COPD.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

B108-09 Integrating the Duke Activity Status Index Into COPD Care: A Simple Approach to Functional and Prognostic Assessment

Q: What are the key findings of this study?

The Duke Activity Status Index (DASI) demonstrated moderate positive correlations with absolute VO2 (r = 0.484, p < 0.001) and relative VO2 (r = 0.441, p < 0.001) during cardiopulmonary exercise testing.

Q: What is the clinical evidence from this study?

Study design: Observational. Population: chronic obstructive pulmonary disease (COPD) (n=102). Intervention: Duke Activity Status Index (DASI) vs. Cardiopulmonary exercise testing (CPET). Primary outcome: Correlation between DASI scores and absolute VO2 during CPET (r = 0.484, p=< 0.001).

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Key result

DASI scores moderately correlate with absolute and relative VO2 during CPET.

r = 0.484
P<0.001
n=102

Why the study?

Routine functional assessment via CPET in COPD is limited by cost and accessibility, and whether the brief DASI questionnaire can estimate functional capacity and predict impairment in COPD remains underexplored.

Does the Duke Activity Status Index (DASI) accurately estimate functional capacity compared to cardiopulmonary exercise testing in individuals with COPD?

Population

102 clinically stable individuals with spirometry-confirmed COPD and no CPET contraindications

Comparison

DASI questionnaire vs CPET variables

Design

Observational longitudinal study

Follow-up

12 months

Authors

IDI M DouradoUniversidade Federal de São Carlos CGC da Luz GoulartPulmonary Hypertension Association AAA D Santos de AraujoUniversidade Federal de São Carlos

Discussion

Member takes

Implication

Multivariable factors explain most VO2 variability during CPET; leaves open translation to improved risk stratification or trial endpoints.

Key Points

The aim is to create a model using the DASI for estimating functional capacity and its role as a prognostic marker in COPD.
Conducted an observational longitudinal study with 102 stable COPD individuals.
Participants completed the DASI questionnaire alongside CPET measurements.
Statistical analyses included Pearson's correlations and multivariable regression to evaluate predictors of VO2.
DASI scores showed moderate positive correlations with absolute VO2 (r = 0.484, p < 0.001) and relative VO2 (r = 0.441, p < 0.001).
DASI VO2, body weight, diastolic blood pressure, and systolic hypertension explained 57.7% of the variance in absolute VO2 during CPET.
DASI provides a valid and accessible method for functional assessment and could enhance prognostic insights in COPD.

Study Design

Type

Observational (n=102)

Structured PICO

Does the Duke Activity Status Index (DASI) accurately estimate functional capacity compared to cardiopulmonary exercise testing in individuals with COPD?

Population

102 clinically stable individuals with spirometry-confirmed COPD and no contraindications to cardiopulmonary exercise testing (CPET) on a cycle ergometer

Intervention

Duke Activity Status Index (DASI) questionnaire

Comparator

Cardiopulmonary exercise testing (CPET) on a cycle ergometer

Outcome

Correlation between DASI scores and CPET parameters (absolute and relative VO2)surrogate

Main Result

Effect estimate: r = 0.484

p-value: p=< 0.001

The DASI questionnaire provides a valid, practical, and accessible alternative for estimating functional capacity in patients with COPD where CPET is not feasible.

Cite This Study

Dourado et al. (2026) conducted an observational in chronic obstructive pulmonary disease (COPD) (n=102). Duke Activity Status Index (DASI) vs. Cardiopulmonary exercise testing (CPET) was evaluated on Correlation between DASI scores and absolute VO2 during CPET (r = 0.484, p=< 0.001). The Duke Activity Status Index (DASI) demonstrated moderate positive correlations with absolute VO2 (r = 0.484, p < 0.001) and relative VO2 (r = 0.441, p < 0.001) during cardiopulmonary exercise testing.

synapsesocial.com/papers/6a0d50aef03e14405aa9c9d6 https://doi.org/10.1093/ajrccm/aamag162.1927

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Implication

Multivariable factors explain most VO2 variability during CPET; leaves open translation to improved risk stratification or trial endpoints.

B108-09 Integrating the Duke Activity Status Index Into COPD Care: A Simple Approach to Functional and Prognostic Assessment

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

B108-09 Integrating the Duke Activity Status Index Into COPD Care: A Simple Approach to Functional and Prognostic Assessment

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

Also Consider