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This review aims to explore the mechanisms behind intestinal barrier disruption in ulcerative colitis and identify strategies for restoration.

Intestinal Barrier: Mechanisms of Disruption and Strategies for Restoration in Ulcerative Colitis

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This review aims to explore the mechanisms behind intestinal barrier disruption in ulcerative colitis and identify strategies for restoration.
Conducted a literature search from 2015 to 2026 in PubMed, Web of Science, and ClinicalTrials.gov.
Summarized intestinal barrier structure, disruption mechanisms, and monitoring approaches.
Reviewed emerging therapies aimed at barrier restoration.
Identified key factors in barrier disruption including proinflammatory cytokines and gut microbiota dysbiosis.
Validated non-invasive monitoring tools include fecal calprotectin/lactoferrin and MRI.
Emerging therapies show promise in stabilizing tight junctions and regulating autophagy.

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Narrative review highlights intestinal barrier mechanisms and therapies for ulcerative colitis management.

Wang et al. (2026) studied this question.

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