Demonstrates high enantioselectivity in quaternary carbon creation using hydroxy enones, suggesting new synthetic methods.
Multinuclear Cu-catalyzed conjugate addition of Me3Al to α’-hydroxy enones was achieved in high to excellent enantioselectivity. In control experiments, we revealed that conjugate addition of Me3Al to β,β-disubstituted α’-hydroxy enones was an important contributor, even without ligands, which implies that the hydroxy moiety helps to facilitate the reaction. The corresponding products can be converted to various carbonyl compounds through oxidative cleavage of the C–C bond.
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Yamamoto et al. (2026) studied this question.
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