What does this research mean for the field?

Switching to high-dose rosuvastatin can induce severe rhabdomyolysis and acute kidney injury requiring hemodialysis, which in turn can precipitate acute coronary syndrome in patients with underlying coronary artery disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To illustrate the complications of statin-induced rhabdomyolysis and subsequent dialysis-induced acute coronary syndrome.

May 20, 2026American Journal of Respiratory and Critical Care Medicine

C49-27 A Double Hit: Statin-induced Rhabdomyolysis Requiring Dialysis Complicated By Hemodialysis-induced Acute Coronary Syndrome

Q: What is the clinical evidence from this study?

Study design: Case Report. Population: Statin-induced rhabdomyolysis, acute kidney injury, and hemodialysis-induced acute coronary syndrome (n=1). Intervention: Rosuvastatin.

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Key result

High-dose rosuvastatin switch triggers severe rhabdomyolysis and AKI complicated by dialysis-induced NSTEMI.

Population

70-year-old male with a past medical history of coronary artery disease, prior percutaneous coronary…

Design

Case_report

Authors

SSS SiddenthiShasta College SSS SuddapalliShasta College DVD VedantamShasta College

Discussion

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Implication

This case highlights the dual risk of statin-induced rhabdomyolysis causing AKI and subsequent hemodialysis-induced ACS in high-risk cardiac patients with CKD.

Key Points

To illustrate the complications of statin-induced rhabdomyolysis and subsequent dialysis-induced acute coronary syndrome.
Detailed case analysis of a 70-year-old male with a history of coronary artery disease and chronic kidney disease.
Laboratory assessments showing severe rhabdomyolysis and subsequent initiation of hemodialysis.
Emergency cardiac catheterization performed after onset of chest pain during the first dialysis session.
CPK elevated to 73,347 U/L and creatinine to 12.48 mg/dL indicating severe rhabdomyolysis leading to acute kidney injury.
NSTEMI with troponin elevation and ECG changes documented during the first dialysis session.
Successful stent placement in the right coronary artery followed by improvement in renal function and stabilization.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 70-year-old male with CAD, prior PCIs, and CKD who developed severe rhabdomyolysis and AKI after switching to rosuvastatin, complicated by NSTEMI during emergent hemodialysis.

Exposure

Rosuvastatin 40 mg daily (switched from atorvastatin 20 mg daily 3 weeks prior)

This case highlights the dual risk of statin-induced rhabdomyolysis causing AKI and subsequent hemodialysis-induced ACS in high-risk cardiac patients with CKD.

Cite This Study

Siddenthi et al. (2026) conducted a case report in Statin-induced rhabdomyolysis, acute kidney injury, and hemodialysis-induced acute coronary syndrome (n=1). Rosuvastatin was evaluated. A 70-year-old male developed severe rhabdomyolysis and AKI 3 weeks after switching to rosuvastatin 40 mg, requiring emergent hemodialysis that subsequently precipitated an NSTEMI.

synapsesocial.com/papers/6a0d5122f03e14405aa9d707 https://doi.org/10.1093/ajrccm/aamag162.5117

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Implication

This case highlights the dual risk of statin-induced rhabdomyolysis causing AKI and subsequent hemodialysis-induced ACS in high-risk cardiac patients with CKD.

C49-27 A Double Hit: Statin-induced Rhabdomyolysis Requiring Dialysis Complicated By Hemodialysis-induced Acute Coronary Syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

C49-27 A Double Hit: Statin-induced Rhabdomyolysis Requiring Dialysis Complicated By Hemodialysis-induced Acute Coronary Syndrome

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

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