An epidemiological analysis of the burden of chronic thromboembolic pulmonary hypertension in the USA, Europe and Japan
Key result
Epidemiological modeling estimates at least ~71% of incident CTEPH cases remain undiagnosed.
Population
Populations in the USA, Europe, and Japan assessed for chronic thromboembolic pulmonary hypertension…
Design
Review
Authors
Discussion
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Member takes
Implication
CTEPH underdiagnosis appears widespread; leaves open true incidence and prospective detection studies.
Structured PICO
P
Population
Populations in the USA, Europe, and Japan assessed for chronic thromboembolic pulmonary hypertension (CTEPH) incidence and diagnosis rates based on 25 publications and 14 databases.
O
Outcome
Incidence and diagnosis rates of CTEPH
CTEPH is significantly underdiagnosed and undertreated across the USA, Europe, and Japan, with incidence projected to increase over the next decade.
Limitations
- Epidemiological data for CTEPH are limited
- Conflicting reports regarding its pathogenesis
Cite This Study
Gall et al. (2017) conducted a review in Chronic thromboembolic pulmonary hypertension (CTEPH). Epidemiological modeling estimated the crude annual incidence of CTEPH at 3-5 cases per 100,000 in the USA and Europe, and 1.9 per 100,000 in Japan, with only 7-29% of cases diagnosed.