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May 20, 2026CureusOpen Access

Extensive Flexural Basal Cell Carcinomas Revealing Gorlin-Goltz Syndrome With Marked Histopathologic Diversity: A Case Report

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Authors

KFKawtar El FidCentre Hospitalier Universitaire Hassan IIZDZakia DouhiSidi Mohamed Ben Abdellah UniversityCBChaimae BouhamdiCentre Hospitalier Universitaire Hassan II

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Implication

Case report reveals unusual flexural presentations of Gorlin-Goltz syndrome with diverse histopathology, indicating diagnosis challenges.

Key Points

  • The aim is to highlight the rare flexural presentation of Gorlin-Goltz syndrome and its histopathological diversity.
  • Descriptive case report of a 42-year-old man with over 30 years of BCC history.
  • Clinical examination and dermoscopy performed to confirm BCC diagnosis.
  • Histopathological analysis identified distinct subtypes of BCC.
  • Confirmed the presence of over 100 lesions (papules, plaques, nodules) with varying histopathological subtypes.
  • X-rays revealed multiple odontogenic keratocysts and bifid ribs, meeting Gorlin-Goltz syndrome criteria.
  • Surgical excision was performed; targeted therapy with vismodegib was considered but not available.

Cite This Study

Fid et al. (2026) studied this question.

synapsesocial.com/papers/6a0d5132f03e14405aa9d91bhttps://doi.org/10.7759/cureus.109102
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