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June 11, 2026CureusOpen Access

Goltz-Gorlin Syndrome: A Case Report and Literature Review

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Authors

SPSandra C. Pérez‐HernándezAZAndrea Zaragoza-NavarroDVDiana Laura Vázquez-Cantú

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Overview

Case report reveals effective treatment options for Goltz-Gorlin syndrome in a female patient, highlighting early recognition importance.

Key Points

  • This report aims to enhance the understanding and awareness of Goltz-Gorlin syndrome through a detailed case presentation and literature review.
  • Reported a case of a 49-year-old woman with Goltz-Gorlin syndrome exhibiting various lesions and abnormalities.
  • Conducted histopathological examination to confirm diagnosis and performed PCR testing for HPV.
  • Provided multidisciplinary management including dental excision and pharmacotherapy with topical 5-fluorouracil and oral isotretinoin.
  • Histopathological confirmation of Goltz-Gorlin syndrome was achieved through examination of skin lesions.
  • Treatment led to complete remission of extensive papillomatous lesions in the patient.
  • A retrospective review identified only two additional cases in the past 15 years, emphasizing the syndrome's rarity.

Cite This Study

Pérez‐Hernández et al. (2026) studied this question.

synapsesocial.com/papers/6a2a508980c8f91e7f39d084https://doi.org/10.7759/cureus.110528
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dental Findings in Goltz Syndrome: A Case Report and Literature Review2025
  2. 2Extensive Flexural Basal Cell Carcinomas Revealing Gorlin-Goltz Syndrome With Marked Histopathologic Diversity: A Case Report2026
  3. 3Phenotypes, Genetics, and Estimated Prevalence of Focal Dermal Hypoplasia (Goltz Syndrome): A Single‐Center Report2024 · 3 citations
  4. 4Gorlin Syndrome: A Series of 10 Patients. Diagnosis, Follow-up, and Treatment from the Dermatological Consultation2026
  5. 5Case Report of Gorlin-Goltz Syndrome2024 · 1 citations