Key result
Hyperthyroidism in rats significantly increased ANF mRNA content in the right atria (176% of euthyroid, P<0.05), left atria (272%, P<0.05), and ventricles (178%, P<0.02).
Why the study?
Does thyroid hormone state modulate ANF mRNA and peptide levels in rat atria and ventricles?
Population
Hypothyroid, euthyroid, and hyperthyroid rats
Comparison
Thyroid hormone modulation vs Euthyroid state
Design
Preclinical
Authors
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May link hyperthyroidism to ANF changes in rats; leaves open human relevance.
Does thyroid hormone state modulate ANF mRNA and peptide levels in rat atria and ventricles?
p-value: p=<0.05
Hyperthyroidism is associated with increased ANF mRNA expression in both atria and ventricles, which may contribute to higher circulating ANF levels.
Ladenson et al. (1988) studied Hypothyroidism and hyperthyroidism. Thyroid hormone state vs. Euthyroid state was evaluated on ANF mRNA and ANF levels in myocardium (p=<0.05). Hyperthyroidism in rats significantly increased ANF mRNA content in the right atria (176% of euthyroid, P<0.05), left atria (272%, P<0.05), and ventricles (178%, P<0.02).
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