What does this research mean for the field?

Both atrial and ventricular myocardium can express the atrial natriuretic factor (ANF) gene, and this expression significantly increases in response to volume overload and passive stretch of the cardiac chambers. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 1, 1986AJP Heart and Circulatory Physiology

Myocardial recruitment during ANF mRNA increase with volume overload in the rat

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Why the study?

Does volume overload increase ANF gene expression in rat myocardium?

Population

Rat models of volume overload

Comparison

Induction of volume overload vs Control rats

Design

Preclinical

Follow-up

48 hours to 3 weeks

Authors

ALAnne-Laure LattionUniversity of Lausanne JMJ B MichelIllinois College EAE. ArnauldInserm

Discussion

Member takes

Implication

Supports ANF upregulation in rat overload models; leaves open translation to human HF remodeling.

Structured PICO

Does volume overload increase ANF gene expression in rat myocardium?

Population

Rat models of volume overload (binephrectomy, ligature of both ureters, deoxycorticosterone acetate-salt, and aortocaval fistula)

Intervention

Induction of volume overload (binephrectomy for 48 h, ligature of both ureters for 48 h, deoxycorticosterone acetate-salt for 3 wk, or aortocaval fistula for 2 wk)

Comparator

Control rats

Outcome

ANF mRNA expression in atrial and ventricular myocardiumsurrogate

Volume overload induces a significant increase in ANF gene expression across both atrial and ventricular myocardium in rat models.

Cite This Study

Lattion et al. (1986) studied this question.

synapsesocial.com/papers/6a135f8371369867e4937d88 https://doi.org/10.1152/ajpheart.1986.251.5.h890

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Myocardial recruitment during ANF mRNA increase with volume overload in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Myocardial recruitment during ANF mRNA increase with volume overload in the rat

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider