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August 1, 1976Canadian Journal of Physiology and Pharmacology

The electrophysiological basis of the motor inhibitory effect of adrenaline on rabbit small intestinal smooth muscle

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Authors

TET. Y. El‐SharkawyUnited Arab Emirates UniversityEDE.E. DanielMedical Council of Canada

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Implication

Randomized trial examines adrenaline's impact on intestinal smooth muscle activity, suggesting a new mechanism of inhibition.

Key Points

  • This research investigates how adrenaline affects the spontaneous electrical activity of small intestinal smooth muscle cells.
  • Examined spontaneous electrical activity and contractions in rabbit small intestinal smooth muscle cells.
  • Utilized temperature-controlled experiments to measure hyperpolarization effects and membrane potential responses.
  • Analyzed the effects of K withdrawal and Cl ion presence on membrane activity.
  • Adrenaline abolished response activity and contractions without affecting control activity or membrane potential.
  • Increased hyperpolarization observed, independent of temperature (Q10 = 1.01).
  • Hyperpolarization was enhanced after K withdrawal but absent after prolonged K withdrawal or Cl replacement.

Cite This Study

El‐Sharkawy et al. (1976) studied this question.

synapsesocial.com/papers/6a0d537dcae7912d2fa4e87ehttps://doi.org/10.1139/y76-064
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Also Consider

Synapse has enriched 2 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Characteristics of Electrogenic Sodium Pumping in Rat Myometrium1970 · 88 citations
  2. 2Responses of muscles of cat small intestine to autonomic nerve stimulation1963 · 27 citations