Key result
Geographic and genealogical analysis demonstrated familial aggregation of calcific aortic valve stenosis, identifying specific clusters with up to 9.38 operated cases per 1000 inhabitants.
Observational (n=2,527)
No
This study demonstrates familial aggregation of calcific aortic valve stenosis, suggesting a genetic or heritable component to the disease.
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May support family screening in high-prevalence clusters; hypothesis-generating for genetic mechanisms and requires prospective validation.
Probst et al. (2006) conducted an observational in Calcific aortic valve stenosis (n=2,527). Geographic and genealogical analysis was evaluated on Geographic distribution and familial aggregation of operated CAVS. Geographic and genealogical analysis demonstrated familial aggregation of calcific aortic valve stenosis, identifying specific clusters with up to 9.38 operated cases per 1000 inhabitants.
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