Key result
Statin therapy is linked to a ~45% slower annual decline in aortic valve area.
Why the study?
Calcific aortic stenosis is hypothesized to be an active inflammatory process similar to atherosclerosis, and it is uncertain whether statin therapy slows its progression.
Does statin therapy reduce the progression of calcific aortic stenosis in patients with mild to moderate disease?
Population
174 patients with mild to moderate calcific aortic stenosis, normal LV function, and ≥2 echocardiograms at least 12 months apart
Comparison
Statin treatment vs no statin treatment
Design
Retrospective cohort study
Follow-up
Mean 21 months
Authors
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Supports hypothesis of statin benefit in mild-moderate aortic stenosis; requires randomized confirmation before practice change.
Cohort (n=174)
Does statin therapy reduce the progression of calcific aortic stenosis in patients with mild to moderate disease?
Absolute Event Rate: 0.06% vs 0.11%
p-value: p=0.03
Retrospective data suggest that statin therapy may slow the echocardiographic progression of mild to moderate calcific aortic stenosis.
Novaro et al. (2001) conducted a cohort in mild to moderate calcific aortic stenosis (n=174). hydroxymethylglutaryl coenzyme A reductase inhibitors (statins) vs. no statin was evaluated on annualized decrease in aortic valve area (cm2) (p=0.03). Statin therapy was associated with a significantly smaller annualized decrease in aortic valve area compared to no statin therapy (0.06±0.16 cm2 vs 0.11±0.18 cm2; P=0.03).
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