Still More Benefits of Statins: Initial Observations in Aortic Stenosis
Key result
Statin therapy was associated with less progression of aortic stenosis, with an annualized reduction in aortic valve area of 0.06 cm2 compared to 0.11 cm2 in patients not taking statins (p=0.03).
Why the study?
Does statin therapy reduce the progression of aortic stenosis in patients with mild-moderate calcific aortic stenosis?
Population
174 patients with mild-moderate calcific aortic stenosis
Comparison
Statin therapy vs No statin therapy
Design
Editorial
Follow-up
mean 21 months
Authors
Discussion
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Implication
Preliminary retrospective data suggest that statin therapy may reduce the echocardiographic progression of mild-to-moderate calcific aortic stenosis.
Study Design
Type
Observational (n=174)
Structured PICO
Does statin therapy reduce the progression of aortic stenosis in patients with mild-moderate calcific aortic stenosis?
P
Population
174 patients with mild-moderate calcific aortic stenosis followed for a mean interval of 21 months.
E
Exposure
Statin therapy
C
Comparator
No statin therapy
O
Outcome
Progression of disease as reflected by changes in aortic valve gradient and area on serial echocardiographic assessmentsurrogate
Main Result
Absolute Event Rate: 0.06% vs 0.11%
p-value: p=0.03
Preliminary retrospective data suggest that statin therapy may reduce the echocardiographic progression of mild-to-moderate calcific aortic stenosis.
Limitations
- Retrospective study design requiring confirmation by a prospective, randomized trial
- retrospective study design
- requires confirmation by a prospective, randomized trial
Cite This Study
Ezra A. Amsterdam (2002) conducted an observational in mild-moderate calcific aortic stenosis (n=174). Statin therapy vs. No statin therapy was evaluated on annualized reduction in aortic valve area (p=0.03). Statin therapy was associated with less progression of aortic stenosis, with an annualized reduction in aortic valve area of 0.06 cm2 compared to 0.11 cm2 in patients not taking statins (p=0.03).