March 24, 2010American Journal of Therapeutics
Statin Therapy and Aortic Stenosis: A Systematic Review of the Effects of Statin Therapy on Aortic Stenosis
Key result
Statin therapy was generally ineffective in delaying the progression of aortic stenosis in randomized controlled trials, and may be associated with a higher incidence of cancer.
Why the study?
Does statin therapy reduce the progression of aortic stenosis in patients with aortic stenosis?
Population
Patients with aortic stenosis
Design
Systematic_review
Authors
Discussion
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Implication
Statin therapy should not be used to slow aortic stenosis progression; challenges prior observational data while confirming RCT results.
Study Design
Type
Systematic Review
Structured PICO
Does statin therapy reduce the progression of aortic stenosis in patients with aortic stenosis?
P
Population
Patients with aortic stenosis
I
Intervention
Statin therapy (HMG-CoA reductase inhibitors)
O
Outcome
Progression of aortic stenosissurrogate
This systematic review demonstrates that statin therapy does not delay the progression of aortic stenosis, challenging earlier observational data.
Cite This Study
Loomba et al. (2010) conducted a systematic review in Aortic stenosis. Statin therapy was evaluated on Progression of aortic stenosis. Statin therapy was generally ineffective in delaying the progression of aortic stenosis in randomized controlled trials, and may be associated with a higher incidence of cancer.